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Research & Development
Chemical & Biotechnological Research and Development
Because new ideas give birth to new possibilities
Over the past few decades, Research and Development of path-breaking products has been a key focus at Ipca. We see tremendous value in our growing R&D investments, and our focused teams at Mumbai and Baroda, are well supported by state of the art equipments and high-end analytical instruments making them self-reliant on in-house product development from simple to complex small molecule drugs as well as biologics. All of our R&D centres are also recognised by the Department of Science and Industrial Research, Government of India, and are supported by facilities required to scale up the processes from grams to kilo as well as to Pilot-Plant level. They have the capabilities to deliver quality solutions within strict timelines, at low costs.
Our product development teams work closely with our marketing teams to produce inventive concepts and ideas, tapping both market needs and synergies across therapeutic domains. To that end, the major activities and expertise of this division includes:
Chemical Research
- New and alternative cost-effective process routes
- Non-infringing processes
- Increasing plant friendliness
- Green chemistry
- Novel polymorphs / derivatives
- Productivity enhancement through continuous batch
- Flow-through continuous process chemistry
- Process engineering
- Impurity and standards synthesis
Analytical Research
- Method development
- Method validation
- Impurity profiling of APIs
- Regulatory compliance meeting global standards
Biosimilar Development
- Focused on r-DNA technology driven products, mainly mAbs, with higher dose of ‘R’ in R+D
- Collaborations with international academic institutes to help remain in the forefront of R&D
- Capabilities / Strengths:
- Cell engineering for high expression and robust platform development
- Process development capabilities from R&D to pilot scale
- Full-fledged formulation, bio-assay and analytical facility
Bio-processing & Metabolic Engineering
- Already a success story in developing and commercialising microbial (bacteria / yeast / fungi / actinomycetes) fermentation products, inaccessible by chemistry alone
- The focus of this unit is to develop strong pipeline of fermentation products to reduce dependency on imports
- Application of Synthetic Biology for developing novel strains giving significant commercial benefits will be the priority for the near future
New Drug Discovery and Development:
- Discovering New Chemical Entities (NCEs)
- Drug repurposing and improvements
- Collaborating with international research organisations
- Current pipeline includes pain-management, anti-platelets and antimalarials
- Few of the NCEs are advanced to clinical & preclinical development phases
- One of the novel molecules (AT-10) has shown very promising anti-platelet activity and is currently in clinical Phase-I trial in USA and India
- Another molecule (Atoguanil) is under clinical development in collaboration with MMV for seasonal malaria chemo-prevention
Intellectual Property Management
- Supported by qualified and expert IPR personnel
- Freedom to operate analysis for the in-house APIs
- Non-infringement alternatives
Awards & Recognition
Our research expertise has not only bagged us tremendous business opportunities, but also earned us unparalleled trust of our partners, and admiration of the industry at large. It has been appreciated in various forums and rewarded:
- CPhI Pharma Excellence Award – Madrid, 2018
- Our inventions have been continuously recognised:
- Best patent award from Pharmexcil in the years 2008, 2009, 2010, 2012, 2013, and 2014
- Best patent award from IDMA in the years 2008, 2009, 2014, and 2016
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